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A revolutionary and non-invasive medical therapy to restore endogenous bioelectrical balance and promote well-being
REAC® Technology
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Trusted by leading institutions worldwide

Anhembi-Morumbi-University
CEPHO
Fudan-University-China
IRET
Fondazione-Regina-Sofia-Madrid
Dipartimento-Scienze-Vita-Universita-degli-Studi-di-Trieste
Università-degli-studi-di-sassari
Universidade-de-Sao-Paulo
FMABC
Ludwing-Boltzmann-Institute

REAC® Technology: non-invasive neuro and biostimulation

Thanks to specific therapeutic protocols, REAC® acts precisely on the causes of numerous functional and organic disorders, offering a personalized, safe and non-invasive treatment approach for each type of patient.

 

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A breakthrough technology

backed by over 30 years of research, clinical validation, and real world application supported by peer-reviewed publications and trusted by medical professionals worldwide.
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REAC® Technology: A Novel Paradigm in Non-Invasive Neuromodulation for Medical Applications
REAC® (Radio Electric Asymmetric Conveyer) Technology is an innovation in the fields of neuromodulation and biomodulation. It is based on the restoration of altered endogenous bioelectrical activity, which is essential for cellular and neurological physiology, and may be disrupted by various factors, including epigenetic changes.

Today, REAC® Technology offers innovative solutions across diverse medical fields including neurology, psychiatry, orthopedics, pain management, and regenerative medicine, significantly improving the quality of life for numerous patients worldwide.

Testimonials from professionals utilizing REAC® Technology

REAC® Technology is trusted by healthcare professionals specializing in rehabilitation, neurology, mental health, physiatry, and traumatology to make a significant difference in the lives of their patients.
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I’m Dr. Castagna, an orthopedic specialist. I’ve been using REAC technology since 2003 with outstanding results: faster recovery times and no side effects. It’s a valuable resource that has transformed my practice. I encourage colleagues to explore it.
Dr. Alessandro Castagna
MD Surgeon / Orthopedic
dr.-monica-urru
I’m Dr. Monica Urru. Since 2008, I’ve used REAC technology for myself and my patients. It transformed my clinical approach and body awareness, relieving chronic pain and dissociative symptoms, and reshaping how I understand somatization.
Dr. Monica Urru
MD Surgeon / ISTDP Teacher and Supervisor (Intensive Short-Term Dynamic Psychotherapy)
giulio_pellegata
With years of clinical experience using REAC Technology, I've witnessed its significant advantages firsthand, both for myself and my patients. It’s a truly transformative approach to patient care and wellness.
Dr. Giulio Pellegata
MD Surgeon / Anesthesiology and Intensive Care
dra-nicoletta-casale
I'm Dr. Nicoletta Casale, a Medical Doctor using REAC neurobiomodulation for over 20 years. It transformed my practice, offering an effective, holistic approach to health. REAC therapy is safe, noninvasive, and delivers lasting clinical results.
Dr. Nicoletta Casale
MD Surgeon

REAC® Technology neuromodulation and biomodulation is revolutionizing non-invasive medicine.

REAC® (Radio Electric Asymmetric Conveyer) technology was conceived by physicians and researchers Salvatore Rinaldi and Vania Fontani at the Rinaldi Fontani Institute in Florence, Italy. Its development is the result of extensive research aimed at understanding the interaction between the environment, epigenetic stress, and the neuro-psycho-physical pathophysiology of the human being.

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Effective, Safe, Painless, Non-invasive

REAC® Technology, developed by the Rinaldi Fontani Institute and powered by ASMED

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Dr. Vania Fontani

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Dr. Vania Fontani MD, PhD, is a prominent figure in the field of regenerative medicine and neurobiological modulation.

She has dedicated her career to research and the development of innovative technologies for human well-being.

Currently, Dr. Fontani holds the position of Scientific Director at the Rinaldi Fontani Institute in Florence, where she leads the Department of Regenerative Medicine.

In collaboration with Prof. Salvatore Rinaldi, she co-developed the REAC® (Radio Electric Asymmetric Conveyer) technology, a non-invasive methodology aimed at modulating endogenous bioelectric activity to promote health and well-being.

Her research work is documented in over 60 scientific publications, with a significant impact in the field of neuromodulation and regenerative medicine.
Her experience and expertise make her an ideal speaker for international events focused on innovation and longevity

Learn more:
• Publications: PubMed – Rinaldi S, Fontani V

Prof. Salvatore Rinaldi

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Physician and researcher, pioneer in neurobiological modulation, regenerative medicine, and anti-senescence therapies Scientific Director – Rinaldi Fontani Institute, Florence, Italy
ORCID: 0000-0002-8961-6316

Profile and Mission

Salvatore Rinaldi is an internationally recognized innovator for his groundbreaking
contribution to the study and clinical application of neurobiological modulation using
asymmetrically conveyed radio-electric signals (REAC). His work has redefined the
boundaries of regenerative medicine and longevity, demonstrating how optimizing
endogenous bioelectrical activity can promote cellular reprogramming, recovery of
compromised functions, and the prevention of age-related decline.

 

Research Milestones

Rinaldi’s research has opened new frontiers in the understanding and treatment of
neurodegenerative diseases and cellular aging processes. Among his most significant
contributions:


Regenerative Medicine:

  • Direct cellular reprogramming through epigenetic modulation of
    endogenous bioelectrical activity with REAC technology.
  • Radiofrequency energy loop primes cardiac, neuronal, and skeletal muscle
    differentiation in mouse embryonic stem cells: a new tool for improving tissue
    regeneration. Cell Transplant. 2012;21(6):1225-33. doi: 10.3727/096368911X600966.
  • Radio electric conveyed fields directly reprogram human dermal skin fibroblasts
    toward cardiac, neuronal, and skeletal muscle-like lineages. Cell Transplant.
    2013;22(7):1227-35. doi: 10.3727/096368912X657297.
  • Neurological morphofunctional differentiation induced by REAC technology in PC12. A
    neuro protective model for Parkinson's disease. Sci Rep. 2015 May 15:5:10439. doi:
    10.1038/srep10439.

Anti-Senescence and Longevity:

  • REAC technology and hyaluron synthase 2, an interesting network to slow down stem
    cell senescence. Sci Rep. 2016 Jun 24:6:28682. doi: 10.1038/srep28682.
  • Stem cell senescence. Effects of REAC technology on telomerase-independent and
    telomerase-dependent pathways. Sci Rep. 2014 Sep 16:4:6373. doi:
    10.1038/srep06373.
  • Anti-senescence efficacy of radio-electric asymmetric conveyer technology. Age
    (Dordr). 2014 Feb;36(1):9-20. doi: 10.1007/s11357-013-9537-8.

Neurodegenerative Diseases – Efficacy of REAC Technology in Alzheimer’s and
Neurodegeneration Models:

  • REAC technology modifies pathological neuroinflammation and motor behaviour in an
    Alzheimer's disease mouse model. Sci Rep. 2016 Oct 24:6:35719. doi:
    10.1038/srep35719.
  • Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a
    Mouse Model of Neurodegeneration. Neurosci Bull. 2018 Apr;34(2):270-282. doi:
    10.1007/s12264-017-0188-0

Scientific Vision

Salvatore Rinaldi’s work demonstrates that bioelectrical modulation is not merely a
theoretical concept, but a concrete and reproducible therapeutic strategy to counteract
aging, support cellular repair processes, and prevent tissue degeneration.

Learn more:
• ORCID Profile: 0000-0002-8961-6316
• Publications: PubMed – Rinaldi S, Fontani V