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Effective, Safe, Painless, Non-invasive

Therapeutic Protocols

REAC Technology®-based therapeutic protocols for Neuromodulation and Biomodulation are engineered to optimize patient neuropsychophysical responses via both targeted and systemic actions. Discover the application fields and unique characteristics pertinent to each protocol
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neruomodulazione-reac

Neuromodulation

The therapeutic neuromodulation protocols based on REAC Technology® are used to treat conditions such as depression, anxiety, stress, behavioral disorders, stress-related disorders, postural issues, and neurological motor disorders. More broadly, they are applied in all situations where dysfunctional psycho-emotional adaptation is a contributing or aggravating factor. These protocols work both in a targeted and systemic manner, with therapeutic and preventive purposes, supporting mental health and longevity.
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Neuromodulation Treatments

Neuromodulation therapies based on REAC Technology® for the treatment of postural and motor disorders, mood and behavioral disorders, and pain syndromes.
neuro-postural-optimizzation-reac

Neuro Postural Optimization (NPO) constitutes a neurobiological stimulation treatment aimed at initiating the optimization of adaptive responses within the central nervous system (CNS). Its primary focus is on neuropsychomotor functions, addressing conditions such as fluctuating asymmetries and functional dysmetrias.
Evidence of the treatment's efficacy includes the immediate resolution of functional dysmetrias, with notable effects observed in the lower limbs.

Mode of Administration:

Application is performed using a handpiece designed for pinpoint delivery to a specific point on the auricle.

Session Duration:

The application consists of a single instance lasting only 250 ms.

Therapeutic Cycle:

The treatment cycle consists of a single session, as the effect is stable over time.

Neuro Muscular Optimization (NMO) is a local neurobiological stimulation treatment. It is applied directly to muscle groups exhibiting asymmetrical activation, necessitating functional rebalancing between agonist and antagonist muscles for rehabilitative purposes and the optimization of neuromuscular management.

Mode of Administration:

It is performed using the ACP, positioned so as to treat the contralateral antagonist muscles.

Session Duration:

Duration: 8 minutes per session. Up to 4 sessions can be administered per day, with an interval of at least one hour between sessions.

Therapeutic Cycle:

Each therapeutic cycle consists of 12 sessions. The interval between consecutive sessions must not exceed 2 weeks. It is recommended to administer 1 to 3 cycles per year, depending on the patient's clinical condition
reac-technology-nppo-neuro-psyco-phisical-optimizzation

Neuro Psycho Physical Optimization (NPPO) therapy involves neurobiological stimulation and is indicated for the symptomatology associated with behavioral and mood disorders.

Mode of Administration:

It is performed by sequentially applying the point probe (handpiece) to 7 specific points on the ear.

Session Duration:

Application at each point necessitates 500 ms. A maximum of 4 sessions may be conducted daily, provided there is a minimum interval of one hour between consecutive sessions.

Therapeutic Cycle:

Each treatment cycle comprises 18 sessions. The interval between consecutive sessions must not exceed two weeks. One to three cycles annually are recommended, based on the patient's clinical condition.

Neuro Psycho Physical Cervico-Brachial Optimization (NPPO-CB) is a neurobiological stimulation therapy utilized for the symptomatology of behavioral and mood disorders.

Its administration is recommended when the symptoms of behavioral and mood disorders are accompanied by muscular tension within the cervico-brachial region.

Mode of Administration:

Application is carried out following the placement of the appropriate ACP onto the cervico-brachial region.

Session Duration:

Session duration is 4 minutes. A maximum of 4 sessions may be performed daily, separated by at least a one-hour interval.

Therapeutic Cycle:

Session duration is 4 minutes. Each therapeutic cycle comprises 18 sessions. Intervals between sessions must not exceed two weeks. Depending on the patient's clinical presentation, one to three treatment cycles annually are advised.
antalgic-neuro-modulation-reac-anm

Neuro Psycho Physical Optimization (NPPO) therapy involves neurobiological stimulation and is indicated for the symptomatology associated with behavioral and mood disorders.

Mode of Administration:

It is performed by sequentially applying the point probe (handpiece) to 7 specific points on the ear.

Session Duration:

Application at each point necessitates 500 ms. A maximum of 4 sessions may be conducted daily, provided there is a minimum interval of one hour between consecutive sessions.

Therapeutic Cycle:

Each treatment cycle comprises 18 sessions. The interval between consecutive sessions must not exceed two weeks. One to three cycles annually are recommended, based on the patient's clinical condition.

Neuro Psycho Physical Cervico-Brachial Optimization (NPPO-CB) is a neurobiological stimulation therapy utilized for the symptomatology of behavioral and mood disorders.

Its administration is recommended when the symptoms of behavioral and mood disorders are accompanied by muscular tension within the cervico-brachial region.

Mode of Administration:

Application is carried out following the placement of the appropriate ACP onto the cervico-brachial region.

Session Duration:

Session duration is 4 minutes. A maximum of 4 sessions may be performed daily, separated by at least a one-hour interval.

Therapeutic Cycle:

Session duration is 4 minutes. Each therapeutic cycle comprises 18 sessions. Intervals between sessions must not exceed two weeks. Depending on the patient's clinical presentation, one to three treatment cycles annually are advised.

Antalgic Neuro Modulation (ANM) constitutes a neurobiological stimulation therapy beneficial for managing pain syndromes.
The procedure involves applying the ACP device directly to the algic (painful) areas targeted for treatment.

Mode of Administration:

This treatment is performed using the ACP, which is positioned over the painful areas requiring treatment.

Session Duration:

Session duration is 15 minutes. A maximum of four sessions may be conducted daily, provided there is an interval of at least one hour between consecutive sessions.

Therapeutic Cycle:

A therapeutic cycle comprises 10 to 20 sessions. Intervals between sessions must not exceed two weeks. Depending on the patient's clinical presentation, one to three treatment cycles annually are advised.
biomodulazione-reac

Biomodulation

REAC Technology-based Biomodulation protocols leverage innovation and expertise to address complex conditions like chronic inflammation and chronic tissue pathologies, including those causing persistent pain and structural/functional changes (e.g., lipedema). These therapies optimize microcirculation and metabolism, accelerate tissue repair and regeneration, and promote anti-senescence.
We are committed to equipping professionals with advanced therapeutic tools to enhance patient well-being and quality of life. The daily positive impact on thousands of lives drives our ongoing pursuit of research and innovation.
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Biomodulation Treatments

Biomodulation therapies based on REAC Technology® for Reparative and Regenerative Processes.
reac-inflammation-and-tissue-disorders

The REAC Anti-Inflammatory Anti-Cellulite (ACT) treatment is an innovative therapeutic solution focused on attenuating inflammation, particularly chronic silent inflammation, which often contributes to the formation and exacerbation of cellulite. Through specific endogenous bioelectrical modulation, the REAC ACT treatment acts at a deep tissue level, reducing tissue inflammation and thereby improving both cutaneous appearance and tissue health.

Mode of Administration:

The ACP probe is positioned onto the area to be treated.

Session Duration:

Each session lasts for 15 minutes. A maximum of four sessions can be performed daily, provided there is a minimum interval of one hour separating consecutive sessions.

Therapeutic Cycle:

Each therapeutic cycle consists of 18 sessions. The interval between consecutive sessions must not exceed two weeks.
reac-circulatory-optimizzation

The REAC Circulatory Optimization (CO) treatment represents an advanced therapeutic approach that enhances circulation, ensuring the effective distribution of oxygen and nutrients to tissues, as well as facilitating the elimination of waste products. Through the specific bioelectrical modulation of the REAC CO treatment, blood and lymphatic flow are optimized, contributing significantly to cellular health and the processes of refined tissue repair and healing.

Mode of Administration:

The ACP probe is positioned onto the area to be treated.

Session Duration:

Each session lasts for 15 minutes. A maximum of four sessions can be performed daily, provided there is a minimum interval of one hour separating consecutive sessions.

Therapeutic Cycle:

Each therapeutic cycle consists of 18 sessions. The interval between consecutive sessions must not exceed two weeks.
reac-metabolic-optimizzation

The REAC Metabolic Optimization (MO) treatment represents an advanced therapeutic approach aimed at enhancing the efficiency of cellular metabolic processes. Through endogenous bioelectrical modulation, specific to the REAC MO treatment, the biochemical reactions involved in energy production and utilization are optimized, thereby promoting metabolic balance and improving cellular functional efficiency. This treatment contributes to systemic well-being by supporting energy metabolism and fostering cellular renewal.

Mode of Administration:

The ACP probe is positioned onto the area to be treated.

Session Duration:

Each session lasts for 15 minutes. A maximum of four sessions can be performed daily, provided there is a minimum interval of one hour separating consecutive sessions.

Therapeutic Cycle:

Each therapeutic cycle consists of 18 sessions. The interval between consecutive sessions must not exceed two weeks.
reac-reparative-medicine

The TO-RPR (Tissue Optimization Reparative) protocol using REAC technology is a biostimulation treatment designed to promote reparative processes in damaged tissues. It works by modulating endogenous bioelectric fields altered by trauma or degeneration, supporting cellular regeneration, reducing inflammation, and facilitating functional recovery. It is indicated in orthopedic, neurological, and rehabilitative settings, including post-surgical phases.

Mode of Administration:

The ACP probe is positioned onto the area to be treated.

Session Duration:

Each session lasts for 15 minutes. A maximum of four sessions can be performed daily, provided there is a minimum interval of one hour separating consecutive sessions.

Therapeutic Cycle:

Each therapeutic cycle consists of 18 sessions. The interval between consecutive sessions must not exceed two weeks.
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Dr. Vania Fontani

dr-vania-fontani-rinaldi-fontani-institute

Dr. Vania Fontani MD, PhD, is a prominent figure in the field of regenerative medicine and neurobiological modulation.

She has dedicated her career to research and the development of innovative technologies for human well-being.

Currently, Dr. Fontani holds the position of Scientific Director at the Rinaldi Fontani Institute in Florence, where she leads the Department of Regenerative Medicine.

In collaboration with Prof. Salvatore Rinaldi, she co-developed the REAC® (Radio Electric Asymmetric Conveyer) technology, a non-invasive methodology aimed at modulating endogenous bioelectric activity to promote health and well-being.

Her research work is documented in over 60 scientific publications, with a significant impact in the field of neuromodulation and regenerative medicine.
Her experience and expertise make her an ideal speaker for international events focused on innovation and longevity

Learn more:
• Publications: PubMed – Rinaldi S, Fontani V

Prof. Salvatore Rinaldi

dr-salvatore-rinaldi-rinaldi-fontani-institu

Physician and researcher, pioneer in neurobiological modulation, regenerative medicine, and anti-senescence therapies Scientific Director – Rinaldi Fontani Institute, Florence, Italy
ORCID: 0000-0002-8961-6316

Profile and Mission

Salvatore Rinaldi is an internationally recognized innovator for his groundbreaking
contribution to the study and clinical application of neurobiological modulation using
asymmetrically conveyed radio-electric signals (REAC). His work has redefined the
boundaries of regenerative medicine and longevity, demonstrating how optimizing
endogenous bioelectrical activity can promote cellular reprogramming, recovery of
compromised functions, and the prevention of age-related decline.

 

Research Milestones

Rinaldi’s research has opened new frontiers in the understanding and treatment of
neurodegenerative diseases and cellular aging processes. Among his most significant
contributions:


Regenerative Medicine:

  • Direct cellular reprogramming through epigenetic modulation of
    endogenous bioelectrical activity with REAC technology.
  • Radiofrequency energy loop primes cardiac, neuronal, and skeletal muscle
    differentiation in mouse embryonic stem cells: a new tool for improving tissue
    regeneration. Cell Transplant. 2012;21(6):1225-33. doi: 10.3727/096368911X600966.
  • Radio electric conveyed fields directly reprogram human dermal skin fibroblasts
    toward cardiac, neuronal, and skeletal muscle-like lineages. Cell Transplant.
    2013;22(7):1227-35. doi: 10.3727/096368912X657297.
  • Neurological morphofunctional differentiation induced by REAC technology in PC12. A
    neuro protective model for Parkinson's disease. Sci Rep. 2015 May 15:5:10439. doi:
    10.1038/srep10439.

Anti-Senescence and Longevity:

  • REAC technology and hyaluron synthase 2, an interesting network to slow down stem
    cell senescence. Sci Rep. 2016 Jun 24:6:28682. doi: 10.1038/srep28682.
  • Stem cell senescence. Effects of REAC technology on telomerase-independent and
    telomerase-dependent pathways. Sci Rep. 2014 Sep 16:4:6373. doi:
    10.1038/srep06373.
  • Anti-senescence efficacy of radio-electric asymmetric conveyer technology. Age
    (Dordr). 2014 Feb;36(1):9-20. doi: 10.1007/s11357-013-9537-8.

Neurodegenerative Diseases – Efficacy of REAC Technology in Alzheimer’s and
Neurodegeneration Models:

  • REAC technology modifies pathological neuroinflammation and motor behaviour in an
    Alzheimer's disease mouse model. Sci Rep. 2016 Oct 24:6:35719. doi:
    10.1038/srep35719.
  • Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a
    Mouse Model of Neurodegeneration. Neurosci Bull. 2018 Apr;34(2):270-282. doi:
    10.1007/s12264-017-0188-0

Scientific Vision

Salvatore Rinaldi’s work demonstrates that bioelectrical modulation is not merely a
theoretical concept, but a concrete and reproducible therapeutic strategy to counteract
aging, support cellular repair processes, and prevent tissue degeneration.

Learn more:
• ORCID Profile: 0000-0002-8961-6316
• Publications: PubMed – Rinaldi S, Fontani V