Italian researchers reveal how REAC Technology modulates breast cancer cell activity by reprogramming endogenous bioelectric signals. A promising path to personalized and less invasive therapies.
In 2024, breast cancer remained the most prevalent cancer in Italy, with 53,686 new diagnoses. In response to this critical health challenge, a groundbreaking Italian study proposes an innovative therapeutic approach rooted in regenerative medicine and bioelectric modulation. The research investigates the potential of REAC Technology (Radio Electric Asymmetric Conveyer) to alter the endogenous bioelectrical activity of breast cancer cells, specifically the MCF7 line.
Published in the Journal of Personalized Medicine and selected as an Editor’s Choice article for Q1 2025, the study titled “Impact of REAC Regenerative Endogenous Bioelectrical Cell Reprogramming on MCF7 Breast Cancer Cells” highlights promising in vitro results. The REAC TO-RGN treatment was shown to modulate tumor cell activity, reduce cell vitality and proliferation, and induce autophagy, a mechanism of intracellular recycling.
These findings suggest a potential non-invasive, personalized therapeutic strategy that could complement or reduce reliance on traditional cancer treatments. The research team includes Dr. Vania Fontani and Dr. Salvatore Rinaldi, co-founders of the Rinaldi Fontani Institute and inventors of REAC Technology, in collaboration with researchers from the University of Sassari.
This study may mark a pivotal step toward a new therapeutic paradigm in oncology, one that leverages bioelectric reprogramming for more effective and patient-centered cancer care.
The original article from La Repubblica can be accessed here.
Dr. Vania Fontani MD, PhD, is a prominent figure in the field of regenerative medicine and neurobiological modulation.
She has dedicated her career to research and the development of innovative technologies for human well-being.
Currently, Dr. Fontani holds the position of Scientific Director at the Rinaldi Fontani Institute in Florence, where she leads the Department of Regenerative Medicine.
In collaboration with Prof. Salvatore Rinaldi, she co-developed the REAC® (Radio Electric Asymmetric Conveyer) technology, a non-invasive methodology aimed at modulating endogenous bioelectric activity to promote health and well-being.
Her research work is documented in over 60 scientific publications, with a significant impact in the field of neuromodulation and regenerative medicine.
Her experience and expertise make her an ideal speaker for international events focused on innovation and longevity
Learn more:
• Publications: PubMed – Rinaldi S, Fontani V
Physician and researcher, pioneer in neurobiological modulation, regenerative medicine, and anti-senescence therapies Scientific Director – Rinaldi Fontani Institute, Florence, Italy
ORCID: 0000-0002-8961-6316
Profile and Mission
Salvatore Rinaldi is an internationally recognized innovator for his groundbreaking
contribution to the study and clinical application of neurobiological modulation using
asymmetrically conveyed radio-electric signals (REAC). His work has redefined the
boundaries of regenerative medicine and longevity, demonstrating how optimizing
endogenous bioelectrical activity can promote cellular reprogramming, recovery of
compromised functions, and the prevention of age-related decline.
Research Milestones
Rinaldi’s research has opened new frontiers in the understanding and treatment of
neurodegenerative diseases and cellular aging processes. Among his most significant
contributions:
Regenerative Medicine:
Anti-Senescence and Longevity:
Neurodegenerative Diseases – Efficacy of REAC Technology in Alzheimer’s and
Neurodegeneration Models:
Scientific Vision
Salvatore Rinaldi’s work demonstrates that bioelectrical modulation is not merely a
theoretical concept, but a concrete and reproducible therapeutic strategy to counteract
aging, support cellular repair processes, and prevent tissue degeneration.
Learn more:
• ORCID Profile: 0000-0002-8961-6316
• Publications: PubMed – Rinaldi S, Fontani V