She has dedicated her career to research and the development of innovative technologies for human well-being.

Currently, Dr. Fontani holds the position of Scientific Director at the Rinaldi Fontani Institute in Florence, where she leads the Department of Regenerative Medicine.

In collaboration with Prof. Salvatore Rinaldi, she co-developed the REAC® (Radio Electric Asymmetric Conveyer) technology, a non-invasive methodology aimed at modulating endogenous bioelectric activity to promote health and well-being.

Her research work is documented in over 60 scientific publications, with a significant impact in the field of neuromodulation and regenerative medicine.
Her experience and expertise make her an ideal speaker for international events focused on innovation and longevity

Learn more:
• Publications: PubMed – Rinaldi S, Fontani V

Profile and Mission

Salvatore Rinaldi is an internationally recognized innovator for his groundbreaking
contribution to the study and clinical application of neurobiological modulation using
asymmetrically conveyed radio-electric signals (REAC). His work has redefined the
boundaries of regenerative medicine and longevity, demonstrating how optimizing
endogenous bioelectrical activity can promote cellular reprogramming, recovery of
compromised functions, and the prevention of age-related decline.

Research Milestones

Rinaldi’s research has opened new frontiers in the understanding and treatment of
neurodegenerative diseases and cellular aging processes. Among his most significant
contributions:

Regenerative Medicine:

• Direct cellular reprogramming through epigenetic modulation of
  endogenous bioelectrical activity with REAC technology.
• Radiofrequency energy loop primes cardiac, neuronal, and skeletal muscle
  differentiation in mouse embryonic stem cells: a new tool for improving tissue
  regeneration. Cell Transplant. 2012;21(6):1225-33. doi: 10.3727/096368911X600966.
• Radio electric conveyed fields directly reprogram human dermal skin fibroblasts
  toward cardiac, neuronal, and skeletal muscle-like lineages. Cell Transplant.
  2013;22(7):1227-35. doi: 10.3727/096368912X657297.
• Neurological morphofunctional differentiation induced by REAC technology in PC12. A
  neuro protective model for Parkinson's disease. Sci Rep. 2015 May 15:5:10439. doi:
  10.1038/srep10439.

Anti-Senescence and Longevity:

• REAC technology and hyaluron synthase 2, an interesting network to slow down stem
  cell senescence. Sci Rep. 2016 Jun 24:6:28682. doi: 10.1038/srep28682.
• Stem cell senescence. Effects of REAC technology on telomerase-independent and
  telomerase-dependent pathways. Sci Rep. 2014 Sep 16:4:6373. doi:
  10.1038/srep06373.
• Anti-senescence efficacy of radio-electric asymmetric conveyer technology. Age
  (Dordr). 2014 Feb;36(1):9-20. doi: 10.1007/s11357-013-9537-8.

Neurodegenerative Diseases – Efficacy of REAC Technology in Alzheimer’s and
Neurodegeneration Models:

• REAC technology modifies pathological neuroinflammation and motor behaviour in an
  Alzheimer's disease mouse model. Sci Rep. 2016 Oct 24:6:35719. doi:
  10.1038/srep35719.
• Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a
  Mouse Model of Neurodegeneration. Neurosci Bull. 2018 Apr;34(2):270-282. doi:
  10.1007/s12264-017-0188-0

Scientific Vision

Salvatore Rinaldi’s work demonstrates that bioelectrical modulation is not merely a
theoretical concept, but a concrete and reproducible therapeutic strategy to counteract
aging, support cellular repair processes, and prevent tissue degeneration.

Learn more:
• ORCID Profile: 0000-0002-8961-6316
• Publications: PubMed – Rinaldi S, Fontani V