Groundbreaking research presented at ISSCR 2025 demonstrates how REAC® biomodulation can protect and rejuvenate stem cells under microgravity conditions.

Hong Kong, June 12, 2025. At the 2025 Annual Meeting of the International Society for Stem Cell Research (ISSCR) held in Hong Kong, a groundbreaking scientific study was presented that could mark a turning point in space medicine and regenerative research.

The research team, composed of scientists from the University of Sassari and the Rinaldi Fontani Institute in Florence, showed that bioelectrical biomodulation using REAC® (Radio Electric Asymmetric Conveyer) technology can counteract the negative effects of microgravity on human stem cells.

In the study, mesenchymal stem cells derived from Wharton’s Jelly (WJ-MSCs) were exposed for 24 hours to simulated microgravity (less than 10-3 g) using a three-dimensional random positioning machine (3D-RPM). The cells were then treated with a cycle of the REAC MO-MG protocol (Metabolic Optimization – Microgravity). The results showed a significant recovery in the expression of key stemness genes (Oct4, Sox2, Nanog) and important epigenetic factors involved in stress response (Sirt1, DNMT1, HSP70). Specifically, the study evaluated cell morphology after REAC-MO-MG and analyzed gene expression of stemness-associated genes (Oct-4, Sox2, and Nanog), and epigenetic factors strictly related to stress response (Sirt1, DNMT1, and HSP70).

This discovery comes at a time of urgent relevance. As recently reported by ESA astronaut and colonel Luca Parmitano, a mission to Mars could lead to a 25% reduction in bone density within just six months, leaving astronauts with skeletal conditions similar to those of a 90-year-old. This degeneration is accompanied by serious muscular, immune, neurological, and cellular alterations. Effectively counteracting these effects is a top priority for future space missions.

“We need technologies that not only mitigate the effects of the space environment on the human body but also enhance the body’s adaptive and regenerative capabilities,” says Professor Salvatore Rinaldi of the Rinaldi Fontani Institute. “REAC® biomodulation is proving to be one of the most promising solutions in this field—not only for space, but for the future of medicine on Earth as well”.

“Our goal is to understand how cells respond to the extreme stress of microgravity and how we can intervene to preserve their vital functions,” explains Professor Margherita Maioli, project leader at the University of Sassari. “The results obtained with REAC® treatment are remarkable: it not only protects the cells but reactivates their full functionality”.

“The use of the REAC® MO-MG protocol is a concrete example of endogenous bioelectrical medicine applied to the space environment,” adds Dr. Sara Cruciani, co-author of the study. “We observed a rapid and significant recovery of key stemness and epigenetic markers. This is a result that opens new possibilities for regenerative medicine on Earth as well”.

“This REAC® protocol is the outcome of years of research into the role of endogenous bioelectrical activity in cellular regulation and stress response,” emphasizes Dr. Vania Fontani, co-inventor of the technology. “Our challenge is to deliver concrete, applicable solutions both in space and in the most advanced clinical settings.”

The study builds on findings previously published in 2018 by the same research group (Scientific Reports, PMID: 29979723), where it was first shown that REAC technology could counteract molecular signs of premature aging in stem cells exposed to extreme conditions.

REAC® treatment is non-invasive, repeatable, and does not require chemical agents or genetic manipulation. It works by interacting with the cells’ endogenous bioelectrical activity, promoting the functional reprogramming of cells toward a more resilient and regenerative state. The study was conducted with the support of Fondazione di Sardegna, the Rinaldi Fontani Institute, and the e.INS – Ecosystem of Innovation for Next Generation Sardinia project (Grant ECS 00000038), funded by the Italian Ministry of University and Research (MUR) under the National Recovery and Resilience Plan (PNRR).

About REAC® Technology and Rinaldi Fontani Institute

The REAC® Technology (Radio Electric Asymmetric Conveyer) was developed by doctors and researchers Dr. Salvatore Rinaldi and Vania Fontani at the Rinaldi Fontani Institute in Florence. Its creation is the result of a long research journey dedicated to understanding the interaction between the environment, epigenetic stress, and the neuro-psycho-physical pathophysiology of the human being. The need to develop REAC® Technology arose from clinical observation of many pathological conditions in which the functional and adaptive origin—often invisible to traditional diagnostic tools—was a determining factor. The aim was to create a technology capable of selectively interacting with alterations in endogenous cellular bioelectrical activity, acting in a non-invasive, side-effect-free manner with a high degree of biological personalization. This approach represents a paradigm shift compared to traditional methods of forced or pharmacological stimulation, positioning REAC® Technology and its specific therapeutic protocols as a truly innovative tool in precision medicine. REAC® Technology represents a non-invasive, multidisciplinary therapeutic platform that works by modulating altered cellular bioelectrical activity. The preset protocols available in the REAC BENE mod.110 devices have been designed to ensure targeted, repeatable, and safe interventions at various functional and clinical levels, marking a significant evolution toward personalized and precision medicine, free from operator-dependent variability. The use of REAC® Technology is permitted for medical doctors, psychologists, rehabilitation therapists, and other health professionals, depending on the protocol applied and always under medical responsibility. REAC® devices are powered by Asmed and currently used in numerous centers across Italy, Brazil, and Europe. Training and certification are accessible through dedicated programs offered by accredited institutions in collaboration with the Rinaldi Fontani Institute.

REAC® Technology Press, PR & Communication contact:
Nadia Tresoro – ntresoro@reactechnology.com – +34 655080195

Download the Press Release in PDF:
Link to PDF file: 12_06_ Heading to Mars with Young Cells.pdf

Download the Scientific Poster in PDF:
Link to PDF file: Poster_ISSCR2025_12-06-25_HongKong.pdf